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  • Title: A suppressor-inducer factor produced by burn trauma-associated T cells.
    Author: Green DR, Wang N, Zheng H.
    Journal: J Burn Care Rehabil; 1987; 8(6):521-6. PubMed ID: 2963827.
    Abstract:
    Six days after a full-thickness scald burn in specific-pathogen free mice, potent suppressive activity was observed in the serum and in supernatants of splenic T cells. The serum activity could be blocked by addition of a monoclonal anti-T suppressor molecule antibody to assay cultures. An examination of the six-day postburn T cell supernatants revealed suppressor inducer T cell (Tsi) activity with a number of characteristics of other Tsi factors described in other systems. These observations further implicate the suppressor T cell pathway in the immunoregulatory sequelae of severe thermal trauma.
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