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  • Title: Distribution of water, fat, and metals in normal liver and in liver metastases influencing attenuation on computed tomography.
    Author: Ueda J, Kobayashi Y, Kenko Y, Koike H, Kubo T, Takano Y, Hara K.
    Journal: Acta Radiol; 1988; 29(1):33-9. PubMed ID: 2964841.
    Abstract:
    The quantity of water, lipid and some metals was measured in autopsy specimens of 8 normal livers, 9 livers with fatty change, and in 12 livers with metastases of various origins. These parameters contribute to the CT number measured in the liver. Water played a major role in demonstration of liver metastases as a low-density area on CT. Other contributory factors include iron, magnesium and zinc. Lipid and calcium had no influence in this respect. Heavy accumulation of calcium in a metastatic lesion gives a high-density area on CT. However, even when a metastatic lesion was perceived on CT as a low-density area, the calcium content of the lesion was not always lower than that of the non-tumour region.
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