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  • Title: Prefrontal cortical blood flow and cognitive function in Huntington's disease.
    Author: Weinberger DR, Berman KF, Iadarola M, Driesen N, Zec RF.
    Journal: J Neurol Neurosurg Psychiatry; 1988 Jan; 51(1):94-104. PubMed ID: 2965218.
    Abstract:
    To examine the relationship between cortical physiology and dementia in Huntington's disease, rCBF during three different behavioural conditions, one of which emphasised prefrontal cognition, was determined by xenon-133 inhalation in 14 patients with Huntington's disease and in matched controls. Cortical rCBF was not reduced in Huntington's disease patients even while they manifested overt prefrontal-type cognitive deficits. Caudate atrophy on CT and rCBF were significantly correlated, but only during the prefrontal behaviour where the correlation was positive. These results suggest a qualification of the subcortical dementia concept as applied to Huntington's disease and implicate an interaction between pathology that is subcortical and cognitive function that is cortical.
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