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  • Title: Nodal and BMP dispersal during early zebrafish development.
    Author: Rogers KW, Müller P.
    Journal: Dev Biol; 2019 Mar 01; 447(1):14-23. PubMed ID: 29653088.
    Abstract:
    The secreted TGF-β superfamily signals Nodal and BMP coordinate the patterning of vertebrate embryos. Nodal specifies endoderm and mesoderm during germ layer formation, and BMP specifies ventral fates and patterns the dorsal/ventral axis. Five major models have been proposed to explain how the correct distributions of Nodal and BMP are achieved within tissues to orchestrate embryogenesis: source/sink, transcriptional determination, relay, self-regulation, and shuttling. Here, we discuss recent experiments probing these signal dispersal models, focusing on early zebrafish development.
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