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  • Title: Histological phases of Bactrim-induced fixed drug eruption. The report of one case.
    Author: Van Voorhees A, Stenn KS.
    Journal: Am J Dermatopathol; 1987 Dec; 9(6):528-32. PubMed ID: 2965526.
    Abstract:
    A case is described of a patient with Bactrim-induced fixed drug eruption (FDE). Histological studies were performed at 1 day and 5 days after the drug exposure. While the 5-day-old lesion showed changes classically recognized as FDE, the 1-day-old lesion showed changes typical of a hypersensitivity response: diffuse spongiosis, dermal edema and hemorrhage, neutrophilic polymorphonuclear leukocyte abscess formations, and large numbers of eosinophils. This report underscores the dynamic cellular changes that occur in the evolving FDE lesion.
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