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  • Title: [125I-BH-8-MeO-N-PAT, a new ligand for the study of 5-HT1A receptors in the central nervous system].
    Author: Ponchant M, Beaucourt JP, Vanhove A, Daval G, Vergé D, Hamon M, Gozlan H.
    Journal: C R Acad Sci III; 1988; 306(4):147-52. PubMed ID: 2965963.
    Abstract:
    Specific radioactive ligands are needed for studying the pharmacological properties and the regional distribution of the different classes of 5-HT1 receptors within the central nervous system. We describe here the synthesis and some characteristics of the first iodinated specific ligand of 5-HT1A receptors. Like its parent compound, the agonist 8-hydroxy-2-(di-n-propylamino)tetralin or 8-OH-DPAT, [125I]-BH-8-MeO-N-PAT, exhibits a high affinity and excellent selectivity for 5-HT1A sites. Its high specific radioactivity makes this ligand a useful tool for studying 5-HT1A receptors in membranes and sections of the rat brain.
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