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  • Title: Development of the Vinylogous Pictet-Spengler Cyclization and Total Synthesis of (±)-Lundurine A.
    Author: Nash A, Qi X, Maity P, Owens K, Tambar UK.
    Journal: Angew Chem Int Ed Engl; 2018 Jun 04; 57(23):6888-6891. PubMed ID: 29663602.
    Abstract:
    A novel vinylogous Pictet-Spengler cyclization has been developed for the generation of indole-annulated medium-sized rings. The method enables the synthesis of tetrahydroazocinoindoles with a fully substituted carbon center, a prevalent structural motif in many biologically active alkaloids. The strategy has been applied to the total synthesis of (±)-lundurine A.
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