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  • Title: Toxicity of trimetrexate on hemopoietic progenitor cells in normal mice.
    Author: Bogliolo GV, Lerza RA, Mencoboni MP, Saviane AG, Pannacciulli IM.
    Journal: Anticancer Res; 1988; 8(2):229-31. PubMed ID: 2966606.
    Abstract:
    Single increasing doses of methotrexate (MTX) and trimetrexate (TMQ) were administered to normal mice. Survival of hemopoietic progenitor cells assayed as CFU-S and GM-CFC was determined 24 hr after drug injection. The survival of each population in TMQ-treated animals was not statistically different from that observed in mice treated with MTX. No difference was observed in time-survival curves of hemopoietic progenitor cells comparing TMQ to MTX. TMQ toxicity at the hematological level thus seems comparable to that of MTX.
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