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  • Title: Comparison of in vivo D-2 dopamine receptor binding of IBZM and NMSP in rat brain.
    Author: Kung HF, Billings JJ, Guo YZ, Mach RH.
    Journal: Int J Rad Appl Instrum B; 1988; 15(2):203-8. PubMed ID: 2966783.
    Abstract:
    In vivo biodistribution of S- and R-isomers of [125I]IBZM in rats showed a significant initial brain uptake (3.20 and 2.67% dose/organ at 2 min, respectively). The wash-out from the brain was slower for the S-isomer. The striatum to cerebellum ratio for [125I]S-IBZM decreased with an increasing dose of cold carrier or spiperone, suggesting that the brain uptake is stereospecific and saturable, and may be related to the binding of D-2 dopamine receptors. In a dual isotope digital autoradiography study [125I]IBZM and [3H]NMSP(N-methylspiperone) show comparable regional cerebral distribution in rats.
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