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  • Title: Effect of an orally administered arotinoid, Ro 15-0778, on sebum production in man.
    Author: Strauss JS, Davey WP, Denton SJ, Stranieri AM.
    Journal: Arch Dermatol Res; 1988; 280(3):152-4. PubMed ID: 2967678.
    Abstract:
    1,2,3,4-Tetrahydro-1,1,4,4-tetramethyl-y-[(E)-alpha-methylstyryl]- naphthalene (Ro 15-0778), a potent inhibitor of sebaceous gland activity in several animal models has been administered to male volunteers in dosages of 1, 2, 3, and 6 mg/kg/day and 2 g/day for 8 weeks. Sebum production was measured before treatment and after 4 and 8 weeks of therapy. At the dosage levels of 1, 2, 3, and 6 mg/kg/day there was no decrease in sebum secretion. With the dosage of 2 g/day, a significant decrease in sebum secretion was seen after 8 weeks of treatment with Ro 15-0778.
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