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  • Title: Mycophenolate mofetil therapy in adult patients with recalcitrant atopic dermatitis.
    Author: Dias-Polak D, Bergman R, Avitan-Hersh E.
    Journal: J Dermatolog Treat; 2019 Feb; 30(1):49-51. PubMed ID: 29683760.
    Abstract:
    BACKGROUND: Patients with severe atopic dermatitis (AD) may require potent immunosuppressive therapy to control their disease. Mycophenolate mofetil (MMF) has been suggested as a safe and effective drug in these cases. OBJECTIVES: To investigate effectiveness and tolerability of oral MMF in adult patients with severe recalcitrant AD. METHODS: During the years 2010-2017 oral MMF 2-3 g/day was administered to adult patients with severe recalcitrant AD who failed other major systemic drugs, or where other drugs, including cyclosporine (CSA), methotrexate, and azathioprine, were contraindicated. RESULTS: Of 9 consecutive adult patients, 4 (44%) responded completely, 2 (22%) had partial response, and 3 (33%) did not respond at all. The MMF therapy was continued for 5-36 months (average 21 months) without major side effects. CONCLUSIONS: Oral MMF may be an effective drug in AD. Due to its good safety profile, it may be recommended as a first-line systemic therapy, or successive to CSA in the long term.
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