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  • Title: Synthesis of novel quinolinomatrine derivatives and their insecticidal/acaricidal activities.
    Author: Huang J, Lv M, Thapa S, Xu H.
    Journal: Bioorg Med Chem Lett; 2018 Jun 01; 28(10):1753-1757. PubMed ID: 29685655.
    Abstract:
    In continuation of our program to discover natural product-based pesticidal agents, a series of new quinolinomatrine derivatives were prepared. Especially three-dimensional structures of five compounds were unambiguously determined by single-crystal X-ray diffraction. Among them, 21-chloroquinolinomatrine exhibited good insecticidal and acaricidal activities against two crop-threatening insect pests, Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.
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