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  • Title: Adenovirus type 12 E1A gene represses accumulation of MHC class I mRNAs at the level of transcription.
    Author: Friedman DJ, Ricciardi RP.
    Journal: Virology; 1988 Jul; 165(1):303-5. PubMed ID: 2968712.
    Abstract:
    The levels of the class I antigens and mRNAs of the major histocompatibility complex (MHC) are greatly diminished in cells transformed by adenovirus type 12 (Ad12). Although the Ad12-transforming gene, E1A, is responsible for reduced class I expression, the site at which E1A blocks accumulation of class I transcripts is not known. In this study, we demonstrate by nuclear run-on assays that in Ad12-transformed mouse cells, E1A acts by reducing the rate of transcription of class I genes.
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