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  • Title: Electrocardiographic Evaluation in Patients With Spinal Muscular Atrophy: A Case-Control Study.
    Author: Falsaperla R, Vitaliti G, Collotta AD, Fiorillo C, Pulvirenti A, Alaimo S, Romano C, Ruggieri M.
    Journal: J Child Neurol; 2018 Jun; 33(7):487-492. PubMed ID: 29687752.
    Abstract:
    BACKGROUND: This study aimed to show the impairment of autonomic cardiac conduction causing bradycardia and/or electrocardiographic alterations in children affected by spinal muscular atrophy type 1 and 2 (SMA 1 and 2). METHODS: We included 25 spinal muscular atrophy patients, admitted from November 2016 to May 2017. All patients underwent an electrocardiographic examination and we studied PR and QRS intervals, P-waves and QRS amplitudes, and heart rate in spinal muscular atrophy patients compared to a control group. RESULTS: In all patients, we found longer PRi and QRSi ( P < .05), lower P-wave and QRS complex amplitudes ( P < .01), and a decreased heart rate ( P < .01) with respect to controls. When we divided our patients into SMA1 and SMA2 subgroups, we found that statistical differences were maintained for P-wave and QRS complex amplitudes and heart rate, but not for PRi and QRSi with respect to controls. CONCLUSION: We suggest the hypothesis of SMN expression on cardiac tissue condition and/or autonomic cardiac conduction.
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