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  • Title: [Targeting chemotherapy of colorectal cancer by monoclonal antibody conjugated antitumor drug].
    Author: Yamaguchi T, Takahashi T.
    Journal: Gan To Kagaku Ryoho; 1988 Apr; 15(4 Pt 2-1):1060-4. PubMed ID: 2968778.
    Abstract:
    Neocarzinostatin (NCS) was conjugated with mouse monoclonal antibody (A7) that specifically reacted with human colorectal carcinomas in vivo and the conjugates (A7-NCS) were administered to patients with colorectal carcinoma. In several cases the size of the metastatic liver tumor was decreased after intraarterial infusion of A7-NCS. No severe adverse effects were observed in any patients who received A7-NCS. These results suggest that missile cancer chemotherapy using monoclonal antibody as a carrier of anticancer drug will be a promising method for use against cancer.
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