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  • Title: [The combined effect of an ethinylestradiol/desogestrel contraceptive combination on blood lipids and parameters of liver function and coagulation].
    Author: Massafra C, Capitani S, Bernabei A, Scillone L.
    Journal: Rev Fr Gynecol Obstet; 1988 Apr; 83(4):251-5. PubMed ID: 2969134.
    Abstract:
    The present study aims to evaluate the contraceptive efficacy of the new combination ethinylestradiol (30 micrograms)/desogestrel (150 micrograms) and, moreover, to demonstrate its low side effects compared to the symptoms present in the pretreatment cycles. In particular the authors took into consideration the changes in serum lipids, and hepatic and coagulation function parameters induced by pill, in 40 healthy women. An interesting result is that the estrogen induced increase of cholesterol-HDL is not antagonized by the desogestrel that has a slight affinity to androgenic receptors and SHBG. This is obviously of great importance in the prevention of atheromatous lesions.
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