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  • Title: Steroid Responsive Atypical Hemolytic Uremic Syndrome Triggered by Influenza B Infection.
    Author: Mittal N, Hartemayer R, Jandeska S, Giordano L.
    Journal: J Pediatr Hematol Oncol; 2019 Jan; 41(1):e63-e67. PubMed ID: 29702545.
    Abstract:
    Atypical hemolytic uremic syndrome (aHUS) is characterized by uncontrolled complement activation leading to thrombotic microangiopathy and severe end-organ damage. The most common trigger for an episode of aHUS in the background of genetic deregulation of the alternative complement pathway is systemic infection. There are only 4 reported cases of aHUS triggered by influenza B thus far. Current accepted therapies for aHUS include plasma exchange and eculizumab. We describe a unique patient with aHUS with a rare membrane cofactor protein mutation triggered by influenza B infection, who achieved complete remission with treatment with high-dose corticosteroids after failure of plasmapheresis.
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