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  • Title: Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.
    Author: Merfeld EC, Dahiya S, Perkins SM.
    Journal: CNS Oncol; 2018 Apr; 7(2):CNS13. PubMed ID: 29708401.
    Abstract:
    AIM: To evaluate the use of chemotherapy and radiation, and their outcomes for patients with astroblastoma. PATIENTS & METHODS: This is a retrospective review of patients extracted from the National Cancer Database. We investigated overall survival (OS) using Kaplan-Meier curves. Cox proportional hazards models were used to correlate OS with risk variables and treatments. RESULTS: OS at 5 years was 79.5%. Patients with high-grade tumors were more likely to receive chemotherapy and radiation. Patients with high-grade astroblastoma who did not receive adjuvant radiation had poor survival. CONCLUSION: Patients with astroblastoma should be treated with curative intent. Radiation is likely beneficial in high-grade astroblastoma. The exact role of radiation and chemotherapy following surgical resection warrant further investigation.
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