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  • Title: A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro.
    Author: Ea-Kim L, Oudart N.
    Journal: Eur J Pharmacol; 1988 Jun 10; 150(3):393-6. PubMed ID: 2970975.
    Abstract:
    An H3-agonist, R alpha methylhistamine strongly relaxed isolated and perfused rabbit middle cerebral artery precontracted with K+. This vasodilatation was not antagonized by either mepyramine or cimetidine but was competitively antagonized by an H3-antagonist, a mixture of impromidine and cimetidine. Histamine activated the H3-sites in this artery since its concentration-response curve (obtained with mepyramine and cimetidine) was parallel to that of R alpha methylhistamine. Our data indicate that H3-sites could exist in the rabbit cerebral artery.
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