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  • Title: [Gamma-aminobutyric acid metabolism in the rat brain after administration of nootropic agents].
    Author: Karaseva TL, Tsapenko ZhN, Golovenko NIa, Timofeeva SE, Luk'ianenko NG.
    Journal: Vopr Med Khim; 1988; 34(3):81-4. PubMed ID: 2971290.
    Abstract:
    N,N-bis-pyrrolidonomethyl-diaza - 18-crown-6 and piracetam, which are structural analogues of gamma-aminobutyric acid (GABA) and exhibit nootropic properties, affected the GABA metabolism, the content of total protein, DNA and RNA in rat brain after long-term administration at pharmacologically active doses of 100 mg/kg and 400 mg/kg, respectively. As compared with control values, content of GABA in rat brain was increased by 40% after administration of N,N-bis-pyrrolodonomethyl-diaza-18-crown-6 and by 28%--after treatment with piracetam. At the same time, activity of GABA transaminase was decreased by 49.4% and 39.8%, respectively, while the decarboxylase activity was unaltered.
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