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  • Title: Biochemical and immunological evidence for a calcium pump in chromaffin granules.
    Author: King SC, Ellenberger TE, Goldin SM.
    Journal: Biochem Biophys Res Commun; 1988 Sep 15; 155(2):656-63. PubMed ID: 2971354.
    Abstract:
    ATP stimulated the accumulation of 45Ca2+ by chromaffin granule ghosts which contained 5 mM oxalate to trap transported calcium within the lumen. Inasmuch as the ATP-dependent 45Ca2+ transport was resistant to 25 mM ammonium acetate as well as the proton ionophore, carbonylcyanide-m-chlorophenylhydrazone, the chromaffin granule proton translocating ATPase does not provide the energy for this process. Instead, we suggest that chromaffin granules contain a calcium translocating ATPase which catalyzes the 45Ca2+ uptake directly. The observation that chromaffin granules bind to a monoclonal antibody raised against a calcium pump from bovine brain supports this hypothesis.
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