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  • Title: A Carbapenem-Based Off-On Fluorescent Probe for Specific Detection of Metallo-β-Lactamase Activities.
    Author: Mao W, Wang Y, Qian X, Xia L, Xie H.
    Journal: Chembiochem; 2019 Feb 15; 20(4):511-515. PubMed ID: 29718572.
    Abstract:
    Metallo-β-lactamase is one of the major clinical threats because this β-lactam-hydrolyzing enzyme confers significant resistance to most β-lactam antibiotics, including carbapenems, among bacterial pathogens. Reported herein is a novel fluorogenic sensor for the specific detection of metallo-β-lactamase activities. This carbapenem-based reagent exhibits excellent selectivity to metallo-β-lactamase over other serine-β-lactamases, including serine carbapenemases. The usefulness of this probe was further demonstrated in the rapid identification of metallo-β-lactamase-expressing pathogenic bacteria.
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