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  • Title: Tyrosinase inhibitory components from the seeds of Cassia tora.
    Author: Lee GY, Cho BO, Shin JY, Jang SI, Cho IS, Kim HY, Park JS, Cho CW, Kang JS, Kim JH, Kim YH.
    Journal: Arch Pharm Res; 2018 May; 41(5):490-496. PubMed ID: 29721815.
    Abstract:
    Ten compounds (1-10) isolated from the seeds of Cassia tora were evaluated for tyrosinase inhibition. Compounds 3, 4, and 7 inhibited tyrosinase enzymatic activity in a dose-dependent manner, with IC50 values of 3.0 ± 0.8, 7.0 ± 0.4, and 9.2 ± 3.4 μM, respectively. Kinetic analyses revealed a mechanism consistent with competitive inhibition. In silico molecular docking showed that compounds 3 and 4 docked in the active site of tyrosinase, whereas 7 interacted with Ala246 and Val248 at outside of the active site, and His244 and Glu256 at inside. Additionally, compounds 3, 4, and 7 suppressed melanogenesis in α-MSH-treated B16F10 melanoma cells at a concentration of 10 μM.
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