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  • Title: Binding of fructose 2,6-bisphosphate to yeast phosphofructokinase.
    Author: Kessler R, Schellenberger W, Nissler K, Hofmann E.
    Journal: Biomed Biochim Acta; 1988; 47(3):221-5. PubMed ID: 2972277.
    Abstract:
    Binding of Fru-2,6-P2 to yeast phosphofructokinase was investigated by ultrafiltration technique. Per mol of subunit of phosphofructokinase (M = 100,000) 0.5 moles of Fru-2,6-P2 are bound. The binding curve proceeds cooperatively (nH = 1.8 +/- 0.2). The apparent affinity constant of Fru-2,6-P2 amounts to about 2.25 +/- 0.12 microM. Fru-1,6-P2 decreases the affinity of yeast phosphofructokinase to Fru-2,6-P2. The data can be described by assuming either competition of Fru-2,6-P2 and Fru-1,6-P2 for the same binding site or conformationally mediated interactions.
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