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  • Title: T4+ (helper phenotype) chronic lymphocytic leukemia: case report with liver failure and literature review.
    Author: Greer JP, Cousar JB, Miller RF, Vogler LB, Goodin JC, Graber SE, Collins RD.
    Journal: Med Pediatr Oncol; 1988; 16(5):356-62. PubMed ID: 2972899.
    Abstract:
    T-cell lymphomas and leukemias are a heterogeneous group of neoplasms found in each anatomic compartment of the T system (marrow, thymus, and various peripheral tissues) and that have varying phenotypic expressions. Histopathologic features of the thymic and peripheral T neoplasms do not fit into a clearly defined pattern, and clinical expressions of T neoplasms are likewise variable. This report describes a 60-year-old man with "chronic" lymphocytic leukemia of T4+ (helper) phenotype. Rapid deterioration in liver function, presumably due to tumor infiltration, was unexpected and has not previously been reported. The unusual clinical and pathologic features are reviewed in the context of T-cell neoplasms, particularly T4+ processes.
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