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  • Title: Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence.
    Author: Fuchi Y, Fukuda T, Sasaki S.
    Journal: Bioorg Med Chem; 2018 Jul 23; 26(12):3254-3260. PubMed ID: 29731311.
    Abstract:
    The 9-hydroxy-1,3-diazaphenoxazine-2-one unit was conjugated with the Eu3+-cyclen complex through a linker. This diazaphenoxazine group was expected as an antenna unit for the excitation of europium ion, and a selective recognition site for 8-oxo-dGTP base. Among the synthesized three derivatives, the highest fluorescence emission was obtained by the complex constructed of an ethylene linker and the cyclen unit with three N,N-dimethylacetamide groups. The Eu3+-cyclen complex exhibited a selective response to the 8-oxo-dGTP in aqueous media by a time-resolved fluorescence assay.
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