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  • Title: Evaluation of total versus partial androgen blockade in the treatment of advanced prostatic cancer.
    Author: Schulze H, Kaldenhoff H, Senge T.
    Journal: Urol Int; 1988; 43(4):193-7. PubMed ID: 2973169.
    Abstract:
    In order to evaluate the proposed benefit of complete androgen blockade in the treatment of patients with advanced prostatic cancer, we initiated a multicenter prospective and randomized study. At the time of this report 99 patients with newly diagnosed, previously untreated prostatic cancer were randomly distributed to one of the following treatments: group I, orchiectomy plus antiandrogen Flutamide; group II, depot LH-RH analog Zoladex plus Flutamide; group III, orchiectomy alone, and group IV, Zoladex alone. Our preliminary data fail to demonstrate a superiority of total androgen blockade over partial androgen blockade in the treatment of patients with advanced cancer of the prostate.
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