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  • Title: Natamycin and Azithromycin Are Synergistic In Vitro against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates.
    Author: Guo H, Zhou L, He Y, Gao C, Han L, Xu Y.
    Journal: Antimicrob Agents Chemother; 2018 Jul; 62(7):. PubMed ID: 29735563.
    Abstract:
    The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and to azithromycin 50 μg/ml against Fusarium solani species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC90 from 64 to 0.031 μg/ml. No antagonism was observed.
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