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  • Title: [Antibiotic therapy protocol using ceftazidime 3g/day alone or in combination with vancomycin or amikacin. In febrile episodes in neutropenic patients].
    Author: Marie JP, Pico JL, Chiche D, Fitoussi F, Delmer A, Baume D, Rio B, Ajchenbaum F, Richet H, Tancrède C.
    Journal: Presse Med; 1988 Oct 26; 17(37):1968-70. PubMed ID: 2973598.
    Abstract:
    In a preliminary study of 21 febrile episodes in neutropenic patients ceftazidime used as empirical treatment in doses of 3 grams per day succeeded in controlling fever in 74 per cent of the cases. Laboratory studies performed in patients with Gram-negative septicaemia showed clinically effective plasma concentrations of the antibiotic. A trial of ceftazidime (3 g/day) administered alone or combined with amikacin or vancomycin is currently in progress in two medical centres. No statistically significant conclusions could be reached from an intermediate study.
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