These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Development of new hypoxic cell radiosensitizer in Japan].
    Author: Mori T, Murayama C.
    Journal: Gan No Rinsho; 1988 Oct; 34(13):1869-74. PubMed ID: 2974089.
    Abstract:
    Basic studies in hypoxic cell radiosensitizers developed in Japan were reviewed. Because of the unsuccessful clinical trials of misonidazole (MISO), many efforts have been made to find a new hypoxic cell sensitizer which is more effective and/or less toxic than MISO. Already over a thousand drugs were tested, but the majority of them did not work in vivo or were very toxic to the animals. Finally four drugs, KU-2285, KIH-801 (802), RK-28 and RP-170, have been proven to be effective both in vitro and in vivo. All of them are derivatives of 2-nitroimidazole. The first two have different side chains of fluorinated amide and acetohydroxamic acid, respectively. The second two both have sugar moieties. Investigations are now under way to find possible clinical applicability.
    [Abstract] [Full Text] [Related] [New Search]