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  • Title: [Effect of heparin and hypobaric hypoxia on the blood electrolyte composition, ATPase activity and the membrane charge of erythrocytes].
    Author: Pustovalov AP, Voronkov IF.
    Journal: Farmakol Toksikol; 1988; 51(5):53-7. PubMed ID: 2974809.
    Abstract:
    The effects of hypoxia (an "altitude" of 6000 m) and heparin on contents of ions of sodium, potassium, calcium, and magnesium in the plasma and erythrocytes, on ATPase activity and erythrocyte membrane charge in albino rats were studied. Heparin was shown to decrease levels of ions of sodium, potassium, in the plasma and erythrocytes, to increase the negative charge of erythrocytes and membrane permeability for potassium ions. Changes in concentrations of sodium, potassium, calcium and magnesium ions after keeping the rats in a barochamber are more marked on the 2nd day than on the 4th day. Na+, K+-ATPase activity of erythrocyte ghosts first decreased, but on the 4th day increased. Heparin action tended to compensate for changes in contents of the studied ions, ATPase activity and erythrocyte membrane changes as well as changes in gradients of potassium, calcium and magnesium ions concentrations in the erythrocyte-plasma system caused by hypobaric hypoxia.
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