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  • Title: T-cell acute lymphoblastic leukemia with severe leukopenia: evidence for suppression of myeloid progenitor cells by leukemic blasts.
    Author: Douer D, Ben-Bassat I, Froom P, Shaked N, Ramot B.
    Journal: Acta Haematol; 1988; 80(4):185-9. PubMed ID: 2975453.
    Abstract:
    A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.
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