These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Back-stimulation of B lymphocytes binding to helper T cell surface antigens.
    Author: Martinez C, Bandeira A, Toribio ML, Coutinho A, Marcos MA, Pereira P.
    Journal: Eur J Immunol; 1988 Dec; 18(12):1895-9. PubMed ID: 2975596.
    Abstract:
    Helper T cells directed to B cell surface determinants activate their "targets" into polyclonal antibody production in vitro and in vivo, but B cells which bind to epitopes on the helper cell surface are preferentially induced. Furthermore, "anti-helper" B cell activation also occurs by "back-stimulation", that is even when the responding B lymphocytes are not specific targets for the inducing helper cells, as long as these are simultaneously activated by appropriate interactions with presenting cells. In our experimental systems, this is the only condition where "bystander" activation can be recorded. These findings suggest mechanisms of auto-antibody production associated with unrelated helper cell activity in vivo.
    [Abstract] [Full Text] [Related] [New Search]