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  • Title: pyABC: distributed, likelihood-free inference.
    Author: Klinger E, Rickert D, Hasenauer J.
    Journal: Bioinformatics; 2018 Oct 15; 34(20):3591-3593. PubMed ID: 29762723.
    Abstract:
    SUMMARY: Likelihood-free methods are often required for inference in systems biology. While approximate Bayesian computation (ABC) provides a theoretical solution, its practical application has often been challenging due to its high computational demands. To scale likelihood-free inference to computationally demanding stochastic models, we developed pyABC: a distributed and scalable ABC-Sequential Monte Carlo (ABC-SMC) framework. It implements a scalable, runtime-minimizing parallelization strategy for multi-core and distributed environments scaling to thousands of cores. The framework is accessible to non-expert users and also enables advanced users to experiment with and to custom implement many options of ABC-SMC schemes, such as acceptance threshold schedules, transition kernels and distance functions without alteration of pyABC's source code. pyABC includes a web interface to visualize ongoing and finished ABC-SMC runs and exposes an API for data querying and post-processing. AVAILABILITY AND IMPLEMENTATION: pyABC is written in Python 3 and is released under a 3-clause BSD license. The source code is hosted on https://github.com/icb-dcm/pyabc and the documentation on http://pyabc.readthedocs.io. It can be installed from the Python Package Index (PyPI). SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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