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  • Title: A Concise Review of the Epidemiology and Diagnostics of Rickettsioses: Rickettsia and Orientia spp.
    Author: Abdad MY, Abou Abdallah R, Fournier PE, Stenos J, Vasoo S.
    Journal: J Clin Microbiol; 2018 Aug; 56(8):. PubMed ID: 29769278.
    Abstract:
    Rickettsioses are globally distributed and caused by the family Rickettsiaceae, which comprise a diverse and expanding list of organisms. These include two genera, Rickettsia and Orientia Serology has been traditionally the mainstay of diagnosis, although this has been limited by cross-reactions among closely related members and diminished sensitivity/utility in the acute phase of illness. Other techniques, such as nucleic acid amplification tests using blood specimens or tissue swabs/biopsy specimens, sequencing, and mass spectrometry, have emerged in recent years for both pathogen and vector identification. This paper provides a concise review of the rickettsioses and the traditional and newer technologies available for their diagnosis.
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