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  • Title: Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia.
    Author: Schwarcz R, Tamminga CA, Kurlan R, Shoulson I.
    Journal: Ann Neurol; 1988 Oct; 24(4):580-2. PubMed ID: 2977086.
    Abstract:
    The concentration of the endogenous excitotoxin quinolinic acid was determined in the cerebrospinal fluid of drug-free patients suffering from Huntington's disease or schizophrenia (control group). In both diseases, quinolinic acid concentrations were highly variable (less than 4-48 nM) but the mean levels for each disease group were not significantly different from each other or from the quinolinic acid concentration of normal cerebrospinal fluid. Analysis of steady-state cerebrospinal fluid quinolinic acid concentration is unlikely to be of value as a diagnostic tool in Huntington's disease.
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