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  • Title: MiR-199a-3p acts as a tumor suppressor in clear cell renal cell carcinoma.
    Author: Liu J, Liu B, Guo Y, Chen Z, Sun W, Gao W, Wu H, Wang Y.
    Journal: Pathol Res Pract; 2018 Jun; 214(6):806-813. PubMed ID: 29773428.
    Abstract:
    OBJECTIVES: To explore the biological function and mechanism of miR-199a-3p in clear cell renal cell carcinoma (CCRCC). METHODS: We investigated the expression of miR-199a-3p in CCRCC through quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Over expression of miR-199a-3p was performed in CCRCC cell lines, and cell growth curve, colony formation capacity, cell invasion, wound healing and cell apoptosis assay were used for investigating the roles of miR-199a-3p in CCRCC. RESULTS: The expression of miR-199a-3p in CCRCC tissues was significantly lower than that in para-carcinoma tissues. Functional assay showed that over expression of miR-199a-3p influenced cell growth, colony formation, cell invasion, cell migration and cell apoptosis in CCRCC cell lines. CONCLUSIONS: Our work suggested that miR-199a-3p was related to cell growth, colony formation, cell invasion, cell migration and cell apoptosis, which might act as a tumor suppressor in CCRCC.
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