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  • Title: Van Wyk Grumbach Syndrome: A Rare Consequence of Hypothyroidism.
    Author: Reddy P, Tiwari K, Kulkarni A, Parikh K, Khubchandani R.
    Journal: Indian J Pediatr; 2018 Nov; 85(11):1028-1030. PubMed ID: 29777468.
    Abstract:
    Long standing hypothyroidism presenting as an ovarian mass has been well described in literature as the Van Wyk Grumbach syndrome (hypothyroidism, isosexual precocious puberty and ovarian mass). Here, authors report this entity in a 11 y 7 mo old girl child who was referred to a surgeon in view of intestinal obstruction along with a multiloculated ovarian cyst. On evaluation, she was found to have raised serum creatinine, short stature, delayed bone age and pituitary enlargement. She was diagnosed with autoimmune thyroiditis and was started on replacement therapy with thyroxine, after which the ovarian cysts regressed. This entity should be kept in mind in cases of ovarian cysts, especially those with isosexual precocity, to prevent unnecessary evaluation and surgical misadventures.
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