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  • Title: Cysteamine-Modified Gold Nanoparticles as a Colorimetric Sensor for the Rapid Detection of Gentamicin.
    Author: Gukowsky JC, Tan C, Han Z, He L.
    Journal: J Food Sci; 2018 Jun; 83(6):1631-1638. PubMed ID: 29786853.
    Abstract:
    UNLABELLED: A simple, rapid, and specific colorimetric method for gentamicin detection using cysteamine-modified gold nanoparticles (cys-AuNPs) has been developed. The maximum residue limits of gentamicin allowed in foods are typically below 100 nM, so an effective detection method for low concentrations of the drug is required. The aggregation of gold nanoparticles (AuNPs) was used as the basis for this method, and adding cysteamine to the AuNPs helped to enhance their aggregative abilities. The cys-AuNPs are capable of detecting gentamicin concentrations as low as 12.45 nM in water, which could be quantified using UV-vis spectroscopy. Samples extracted from skim milk with a simple pretreatment showed that gentamicin concentrations down to at least 100 nM could be observed using the cys-AuNPs. This study demonstrates the ability of the cys-AuNPs to rapidly detect and quantify gentamicin in both simple and complex matrices. PRACTICAL APPLICATION: This study demonstrates that cysteamine-modified gold nanoparticles could be used as a rapid and efficient tool for gentamicin detection. This technique is cheaper, simpler, and more effective than many other methods that are currently used for detecting the antibiotic in industrial and commercial applications. It has a great potential to be practically applied as a rapid screening method for gentamicin and gentamicin-like compounds in food and environmental samples.
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