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  • Title: Animal experiments as a model for clinical trials of a new dosage form of mitomycin C for peritoneal carcinomatosis.
    Author: Hagiwara A, Takahashi T, Lee R, Ueda T, Takeda M, Itoh T.
    Journal: In Vivo; 1987; 1(1):43-6. PubMed ID: 2979763.
    Abstract:
    Rabbits with peritoneal carcinomatosis induced by VX2 carcinoma were used as an experimental model to study a new dosage form of mitomycin C, MMC-CH, comprising activated carbon adsorbing mitomycin C. Rabbits revived an intraperitoneal injection of mitomycin C (1 mg/kg in the form of MMC-CH or 0.185 mg/kg in the form of mitomycin C solution). The two doses were equal in toxicity. MMC-CH extended survival time measured in days to 139% as compared to mitomycin C solution. Autopsy findings showed peritoneal carcinomatosis to be much less developed with MMC-CH than with mitomycin C solution. Hematological and blood biochemical analyses showed no remarkable abnormality.
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