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  • Title: Cervical myelography with iohexol and metrizamide. A randomized double blind clinical study.
    Author: Servo A, Porras M, Jääskinen J, Virta A, Laasonen EM.
    Journal: Acta Radiol Suppl; 1986; 369():528-31. PubMed ID: 2980548.
    Abstract:
    A randomized double-blind study with iohexol and metrizamide in cervical myelography was performed in 100 patients. The concentration of the contrast medium was 240 mg I/ml. The image quality was equal with both contrast media. Forty-two per cent of the patients receiving iohexol had side effects (headache 22%, nausea 6%, vomiting 2% and mental reactions 6%), in contrast to 80 per cent of the patients receiving metrizamide (headache 56%, nausea 34%, vomiting 24% and mental reactions 26%). The majority of side effects appeared within 6 hours after injection of contrast medium. Two patients had a late onset of symptoms - one in each group. Once appearing, the side effects tended to be equally severe.
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