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  • Title: Chlorpromazine vs. meperidine in the treatment of phencyclidine psychosis.
    Author: Giannini AJ, Loiselle RH, Price WA, Giannini MC.
    Journal: J Clin Psychiatry; 1985 Feb; 46(2):52-4. PubMed ID: 2981827.
    Abstract:
    Patients with phencyclidine psychosis were treated with two 50 mg injections of either chlorpromazine (N = 10) or meperidine (N = 10). The chlorpromazine-treated group responded more rapidly, but the meperidine-treated group had greater overall improvement. It is suggested that meperidine may have a role in the emergency treatment of phencyclidine psychosis. These findings may provide support for the hypothesis that dopaminergic psychosis is mediated by opioids.
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