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  • Title: Ultrastructural localization of the herpes simplex virus major DNA-binding protein in the nucleus of infected cells.
    Author: Puvion-Dutilleul F, Laithier M, Sheldrick P.
    Journal: J Gen Virol; 1985 Jan; 66 ( Pt 1)():15-30. PubMed ID: 2981957.
    Abstract:
    Using immunocytochemical procedures in conjunction with electron microscopy we have examined the distribution of the major DNA-binding protein (DBP) of herpes simplex virus (HSV) in infected nuclei. In embedded specimens, DBP was preferentially associated with fibrillar material of electron-translucent viral inclusions, and to a lesser extent with peripheral (marginated) host chromatin. The latter association was sensitive to a non-ionic detergent ('Photo flo'). In chromatin spread by the Miller technique, DBP was found to be a component of the 10 nm 'thick filaments' previously described in HSV infection.
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