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  • Title: Trophic effects of potassium loading on the rat zona glomerulosa: permissive role of ACTH and angiotensin II.
    Author: Mazzocchi G, Rebuffat P, Robba C, Malendowicz LK, Nussdorfer GG.
    Journal: Acta Endocrinol (Copenh); 1985 Jan; 108(1):98-103. PubMed ID: 2982240.
    Abstract:
    The trophic effects of chronic potassium loading on the rat zona glomerulosa were investigated by morphometric and radioimmunological methods. Potassium loading exerted a potent adrenoglomerulotrophic effect in saline treated control rats, but it was not able to reverse the captopril- and dexamethasone-induced atrophy of the zona glomerulosa. However, if the captopril/dexamethasone administered rats were given maintenance doses of angiotensin II and ACTH, potassium loading was found to exert a strong trophic action. The hypothesis is advanced that potassium loading requires the integrity of both the renin-angiotensin system and the hypothalamo-hypophyseal axis to exert its powerful direct stimulating effect on the growth and steroidogenic capacity of the rat zona glomerulosa.
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