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  • Title: Hypoalbuminemia-related platelet hypersensitivity in two dogs with nephrotic syndrome.
    Author: Green RA, Russo EA, Greene RT, Kabel AL.
    Journal: J Am Vet Med Assoc; 1985 Mar 01; 186(5):485-8. PubMed ID: 2982777.
    Abstract:
    Platelet aggregation studies in 2 dogs with nephrotic syndrome disclosed increased platelet sensitivity to a low dose of adenosine diphosphate. Subsequent studies with isolated platelets and plasma indicated that a plasma factor was responsible primarily for inducing platelet hypersensitivity. The increased platelet aggregation response was corrected by increasing the albumin concentration of the plasma. The study suggested an important role for albumin in modulating platelet aggregation and may partially explain the tendency toward thrombosis noted in hypoalbuminemic dogs with nephrotic syndrome.
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