These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Low activity of angiotensin-converting enzyme in cerebral microvessels of young spontaneously hypertensive rats.
    Author: Kobayashi H, Wada A, Izumi F, Take K, Magnoni MS.
    Journal: J Neurochem; 1985 Apr; 44(4):1318-20. PubMed ID: 2983030.
    Abstract:
    Angiotensin-converting enzyme (ACE) activity was measured in microvessels prepared from cerebral cortices of 4-week-old spontaneously hypertensive rats (SHR). The Vmax value of the ACE activity in the cerebral microvessels of SHR was lower than that of Wistar Kyoto controls of the same age by 25% without difference in Km value for substrate. The low activity of ACE in the cerebral microvessels of young SHR indicates that in this animal model of hypertension the function of ACE is genetically altered in the cerebral microvessels, which may be correlated with the alteration of the cerebral microcirculation and pathogenesis of hypertension.
    [Abstract] [Full Text] [Related] [New Search]