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  • Title: [Effect of an increase in the intracellular concentration of calcium ions on the transmembrane current induced by iontophoretic injection of cAMP into Helix pomatia neurons].
    Author: Kononenko NI, Shcherbatko AD.
    Journal: Neirofiziologiia; 1985; 17(1):78-84. PubMed ID: 2983244.
    Abstract:
    The effect of intracellular Ca2+ concentration increase on transmembrane current induced by cAMP injection into a neuron (cAMP-current) was studied on Helix pomatia neurons under voltage clamp conditions. The elevation of intracellular Ca2+ concentration was produced by iontophoretic injection of Ca2+ into the cytoplasm, generation of action potentials, addition of uncouplers of oxidative phosphorylation into the external solution resulting in Ca2+ efflux from mitochondria. It was found that elevation of the intracellular Ca2+ concentration increases the amplitude of the cAMP-current and in most cases its duration as well. It is suggested that membrane structures responsible for the cAMP-current have two centers of phosphorylation: cAMP-dependent and Ca2+-calmodulin-dependent. Possible role of the studied process in integration of signals on the intraneuronal level is discussed.
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