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  • Title: Effect of captopril on blood pressure and renal function in patients with transplant renal artery stenosis.
    Author: van der Woude FJ, van Son WJ, Tegzess AM, Donker AJ, Slooff MJ, van der Slikke LB, Hoorntje SJ.
    Journal: Nephron; 1985; 39(3):184-8. PubMed ID: 2983251.
    Abstract:
    We evaluated 9 patients with transplant renal artery stenosis. Captopril treatment always resulted in a dramatic decrease in renal function. Moreover, only in patients (n = 2) with a stenosis in one out of more renal arteries a satisfying fall in blood pressure was achieved. Surgical reconstruction of the stenosis was successful in 4 out of 5 patients. Angiotensin I-converting enzyme inhibition in transplant renal artery stenosis often leads to loss of graft function, probably due to efferent vasodilation.
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