These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Blockade of intrathecal 5-hydroxytryptamine-induced antinociception in rats by noradrenaline depletion.
    Author: Minor BG, Post C, Archer T.
    Journal: Neurosci Lett; 1985 Feb 28; 54(1):39-44. PubMed ID: 2983267.
    Abstract:
    The analgesic effect of 5-hydroxytryptamine (5-HT, 200 and 250 micrograms/kg) administered into the lumbar intrathecal space of rats was blocked in the tail-flick, hot-plate and shock titration tests of nociception when the animals had previously been treated with N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), which depletes noradrenaline in the spinal cord. These results suggest an important modulatory role of noradrenaline upon spinal 5-HT mechanisms.
    [Abstract] [Full Text] [Related] [New Search]