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  • Title: [Postradiation inhibition of poly ADP ribose polymerase is not determined by internucleosomal fragmentation of DNA].
    Author: Nelipovich PA, Nikonova LV, Umanskiĭ SR.
    Journal: Radiobiologiia; 1985; 25(1):7-11. PubMed ID: 2983366.
    Abstract:
    Postirradiation changes in poly(ADP-ribose) polymerase activity in nuclei and permeable thymocytes were studied. The incorporation of 14C-NAD into poly(ADP-ribose) was virtually invariable during the first 60 min after irradiation at a dose of 10 Gy, but after 2 and 3 h it made up, as compared to the control, 60 and 45% for nuclei, and 65 and 55% for permeable thymocytes, respectively. It was shown that the internucleosomal fragmentation of DNA was not responsible for the observed changes in poly(ADP-ribose) polymerase activity.
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